Fine-mapping the MHC region in Asian populations identified novel variants modifying susceptibility to lung cancer

Na Qin,Cheng Wang,Meng Zhu,Qun Lu,Zijian Ma,Mingtao Huang,Juncheng Dai,Hongxia Ma,Guangfu Jin,Zhibin Hu,Hongbing Shen

Lung Cancer（2017）

引用 0|浏览0

暂无评分

摘要

•We conducted a fine-mapping study of the MHC region in 13,945 Asian individuals.•Three independent loci were found significantly associated with lung cancer risk.•We identified a multiplicative interaction effect between rs12333226 and age.•Rs12333226 is a eQTL of HLA-A and HLA-H in monocytes.•HLA-DRβ1 positions 10, 16 and 25 may drive the effect of a reported SNP rs2395185.

查看译文

关键词

Lung cancer,Genome-wide association study,Fine mapping,Human leukocyte antigen

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要