Quality of life in adults with epilepsy is associated with anticonvulsant polypharmacy independent of seizure status.

•Polypharmacy is associated with worse quality of life in patients with epilepsy.•Sleepiness, mood disorder, and insomnia were not associated with polypharmacy.•The QOLIE-10-P domains that were most affected were epilepsy and role functioning domains.•This supports the use of the fewest number of effective AEDs in managing seizures.