Construction of a novel vaccine by conjugating a B-cell epitope of DPP4 to peptide IA2(5)-P2-1 to significantly control type 1 diabetes in NOD mice.

Ya Li,Huimin Cao,Yiping Li,Zhixin Li,Xiaomin Wei,Rui Jiao,Peng Cheng,Xiaoran Liu,Yanjie Ma,Yun Xing,Jiali Tang,Min Wang,Taiming Li

Vaccine（2017）

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摘要

•A multi-epitope peptide vaccine based on DPP4 is constructed for type 1 diabetes treatment.•The mechanism relies on inhibition of DPP4 activity and immune rebalance’s reestablishment.•The novel vaccine significantly control type 1 diabetes in NOD mice.

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关键词

Type 1 diabetes,Vaccine,Epitope,Antibody,NOD mice

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