A novel vector for transgenesis in the rat CNS

Acta neuropathologica communications, Volume 5, Issue 1, 2017, Pages 84-84.

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Keywords:
ScrapieVectorPrnpNeurodegenerative disease

Abstract:

The larger brain of the rat enables a much greater repertoire of complex behaviors than mice, likely making rats preferential for investigating neurodegeneration. Because molecular tools for specific expression of transgenes in the rat brain are sparse, we chose Prnp encoding the prion protein (PrP) to develop a novel vector to drive tran...More

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