Ppar Gamma Alleviates Right Ventricular Failure Secondary To Pulmonary Arterial Hypertension In Rats

Pulmonary arterial hypertension (PAH) is characterized by pulmonary vascular remodeling leading to right ventricular hypertrophy (RVH) and failure. Peroxisome proliferator-activated receptor gamma (PPAR gamma), a member of nuclear receptors, has been proved to ameliorate PAH. However, its effect on PAH-induced right ventricular failure (RVF) remains unknown. Therefore, we investigated the therapeutic potential of PPAR gamma in preventing monocrotaline (MCT)-induced RV dysfunction. The PAH model was induced by MCT administration. Male rats were administered with MCT to develop PAH and RVF formed by approximately day 30. Significant increase in RV area, RYAW resulted in an ascending RV index. However, the LV function including EF, FS, and LVID did not change significantly. PPAR gamma agonist prevented PAH-induced RVF by preserving RV index and preventing RVH. PPAR gamma's beneficial effects seem to result from various factors, including anti-apoptosis, preservation RV index, reversal of inflammation, improvement of glucolipid metabolism, reduction of ROS. In a word, PPAR gamma agonist prevents the development of RVF.