Nab-Paclitaxel/Carboplatin Induction In Squamous Nsclc: Longitudinal Quality Of Life While On Chemotherapy

Background: Longitudinal data on the impact of treatment on quality of life (QoL) in advanced non-small cell lung cancer (NSCLC) are limited. In this palliative setting, treatment that does not deteriorate QoL is key. Here we report longitudinal QoL in patients with squamous NSCLC, receiving <= 4 cycles of nab-paclitaxel/carboplatin combination chemotherapy.Methods: Patients received nab-paclitaxel 100 mg/m(2) days 1, 8, 15 + carboplatin area under the curve 6 mg*min/mL day 1 (q3w) for four cycles. QoL was assessed by the Lung Cancer Symptom Scale (LCSS) and Euro-QoL-5 Dimensions-5 Levels (EQ-5D-5L) at baseline and each cycle (day 1).Results: Two-hundred and six lesion-response-evaluable patients completed baseline + >= 1 postbaseline QoL assessment and were QoL evaluable. LCSS average total score and symptom burden index improved from baseline throughout four cycles. In the LCSS pulmonary symptoms score, 46% of patients reported clinically meaningful improvement (>= 10 mm visual analog scale) from baseline. Individual EQ-5D-5L dimensions remained stable/improved in >= 83% of patients; approximate to 33% reported complete resolution of baseline problems at least once during four cycles. Generally, responders (unconfirmed complete/partial response) had higher scores vs nonresponders.Conclusion: In patients with squamous NSCLC, four cycles of nab-paclitaxel/carboplatin demonstrated clinically meaningful QoL improvements, with greater benefits in responders vs nonresponders.