Angiotensin II receptor blockers suppress the release of stromal cell-derived factor-1α from infarcted myocardium in patients with acute myocardial infarction.

Toru Yoshizaki,Manabu Uematsu,Jun-Ei Obata,Takamitsu Nakamura,Daisuke Fujioka,Kazuhiro Watanabe,Kazuto Nakamura,Kiyotaka Kugiyama

Journal of Cardiology（2018）

引用 4|浏览9

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摘要

•Stromal cell-derived factor-1α (SDF-1α) was released from infarcted myocardium in patients with acute myocardial infarction (AMI).•Angiotensin II type I receptor blocker (ARB) treatment suppressed release of SDF-1α from infarcted myocardium in humans.•Clinical study showing anti-inflammatory action of ARB in infarcted myocardium.•A mechanism for beneficial effects of ARB on left ventricular dysfunction in AMI survivors.

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关键词

Angiotensin II receptor blocker,Chemokines,Acute myocardial infarction,Inflammation

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