Hepatitis C virus-induced natural killer cell proliferation involves monocyte-derived cells and the OX40/OX40L axis.
Journal of Hepatology(2018)
摘要
•NK cells upregulate CD25 and proliferate in response to HCV-infected hepatocytes.•NK proliferation requires the presence of T cells and monocytes.•The surface molecule OX40 becomes induced on the subset of activated NK cells.•NK cell proliferation involves cell–cell contact interactions between OX40 and the OX40 ligand.
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关键词
Natural killer cells,Hepatitis C virus,OX40,OX40L,NK cell–monocyte crosstalk
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