Thrombomodulin alfa attenuates the procoagulant effect and cytotoxicity of extracellular histones through the promotion of protein C activation.

•Histones were reported to increase thrombin generation and endothelial cell death.•The effect of thrombomodulin alfa on histones was investigated in this study.•Thrombomodulin alfa increased protein C activation that was inhibited by histones.•Thrombomodulin alfa attenuated the procoagulant effect and cytotoxicity of histones.