Increased frequencies of th17 cells and IL17a-producing regulatory T-cells preceding the immunodiscordant response to antiretroviral treatment.

Isaac Rosado-Sánchez,Inés Herrero-Fernández,Laura Tarancon-Diez,Santiago Moreno,Jose Antonio Iribarren,David Dalmau,Francisco Vera-Méndez,Manuel Leal,Yolanda María Pacheco

Journal of Infection（2018）

引用 8|浏览21

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摘要

•Increased Th17 frequency and IL17a-cytokine-combinations precede immunodiscordance.•Increased IL17a-producing Treg frequency precedes immunodiscordance.•Though increased both cellular subsets, no alteration in Treg/Th17 ratio precedes immunodiscordance.

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关键词

Th17,IL17a-producing Treg,Polifunctionality,Low CD4 recovery,Immunodiscordant response to cART,CD4 T-cell homeostasis

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