NPT088 reduces both amyloid-β and tau pathologies in transgenic mice.

Jonathan M Levenson,Sally Schroeter,Jenna C Carroll,Valerie Cullen,Eva Asp,Ming Proschitsky, Charlotte H-Y Chung,Sharon Gilead,Muhammad Nadeem,Hemraj B Dodiya, Shadiyat Shoaga,Elliott J Mufson,Haim Tsubery,Rajaraman Krishnan,Jason Wright,Beka Solomon,Richard Fisher,Kimberley S Gannon

Alzheimer's & Dementia: Translational Research & Clinical Interventions（2016）

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摘要

•NPT088 binds to and remodels misfolded aggregates of both Aβ and tau.•Systemic administration of NPT088 improves cognition, reduces levels of Aβ42 and lowers fibrillar Aβ plaque in aged Tg2576 hAPP mice.•NPT088 does not increase levels of Aβ in CSF.•Systemic administration of NPT088 improves cognition, improves motor function, reduces phospho-tau and reduces brain atrophy in rTg4510 tau mice.

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关键词

GAIM,General amyloid interaction motif,Novel object recognition,Spontaneous alternation,Limb clasping,Thioflavin S,Brain weight,Cerebrospinal fluid,Phospho-tau

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