Echocardiographic evaluation of diastolic function in mouse models of heart disease.

•Several echocardiographic indices of diastolic function are applicable to mouse models.•Isovolumic relaxation time (IVRT) and peak strain during filling are easily quantified.•Left atrial area increases with pressure and volume overload as well as HFpEF.•Changes in IVRT and strain during filling distinguish restrictive physiology.•Combined left atrial area and diastolic strain provide an ideal diagnostic framework.