Genetic polymorphisms in angiogenesis-related genes are associated with worse progression-free survival of patients with advanced gastrointestinal stromal tumours treated with imatinib.

Michiel C Verboom,Jacqueline S L Kloth,Jesse J Swen,Tahar van der Straaten,Judith V M G Bovée,Stefan Sleijfer,Anna K L Reyners,Ron H J Mathijssen,Henk-Jan Guchelaar,Neeltje Steeghs,Hans Gelderblom

European Journal of Cancer（2017）

引用 13|浏览21

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摘要

•Progression-free survival (PFS) was associated with metastases at diagnosis and KIT exon 9 mutation.•rs1870377 in KDR and rs1570360 in VEGFA were associated with worse PFS.•rs4149117 in SLCO1B3 showed a trend for an association with PFS.

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关键词

GIST,Imatinib,SNPs,Pharmacogenetic pathway analysis,VEGF,Survival

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