Association between SORL1 polymorphisms and the risk of Alzheimer's disease.

A meta-analysis was performed to identify empirical data assessing the effects of a single nucleotide polymorphisms of sortilin-related receptor on Alzheimer's disease based on 14 studies involving 37941 cases and 49727 control studies. Analysis showed, (i) Increased risk between the single nucleotide polymorphisms (rs641120, rs1010159) and Alzheimer's disease susceptibility in Asian populations, (ii) Single nucleotide polymorphism rs689021 was associated with decreased risk in Caucasians, and (iii) Single nucleotide polymorphism rs641120 was detected as a decreased risk in both populations. Given these data, crucial evidence is provided to demonstrate that a significant relationship exists between SORL1 polymorphisms and susceptibility to Alzheimer's disease.