Renal Denervation Reduces Pulmonary Vascular Remodeling and Right Ventricular Diastolic Stiffness in Experimental Pulmonary Hypertension.

•Neurohormonal dysfunction (increased sympathetic nervous system and renin angiotensin-aldosterone system) play an important role in pulmonary hypertension progression.•In this proof-of-concept study we demonstrated in 2 pulmonary hypertension rat models that renal denervation therapy improved pulmonary vascular remodeling, lowered right ventricular afterload, and decreased right ventricular stiffness.•Renal denervation effects may be associated with a suppression of the renin-angiotensin-aldosterone system.