Polypharmacology-based ceritinib repurposing using integrated functional proteomics

Brent M Kuenzi,Lily L Remsing Rix,Paul A Stewart,Bin Fang,Fumi Kinose,Annamarie T Bryant,Theresa A Boyle,John M Koomen,Eric B Haura,Uwe Rix

NATURE CHEMICAL BIOLOGY（2017）

引用 57|浏览72

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摘要

systems chemical biology approach to characterize beneficial off-target effects revealed a polypharmacology mechanism for the multikinase inhibitor ceritinib and a repurposing opportunity through rational design of a synergistic drug combination.

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关键词

Cancer therapy,Kinases,Networks and systems biology,Proteomics,Chemistry/Food Science,general,Biochemical Engineering,Biochemistry,Cell Biology,Bioorganic Chemistry

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