Altered expression of genes involved in programmed cell death in primary cultured rat cerebellar granule cells acutely challenged with tetrabromobisphenol A.

Jacek Lenart,Elzbieta Zieminska,Dominik Diamandakis,Jerzy W Lazarewicz

NeuroToxicology（2017）

引用 14|浏览14

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摘要

•The viability of primary CGC continuously declines after acute challenge with TBBPA.•Genes related to programmed necrosis are not induced in CGC by TBBPA.•Early suppression by TBBPA of the autophagy and apoptotic genes in CGC.•Delayed activation in TBBPA-treated CGC of genes associated with apoptosis.

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关键词

Brominated flame retardants,Primary neuronal cultures,Neurotoxicity,Necrosis,Apoptosis,Autophagy

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