Effects of crenolanib, a nonselective inhibitor of PDGFR, in a mouse model of transient middle cerebral artery occlusion

Jianping Wang,Xiaojie Fu, Di Zhang,Lie Yu,Zhengfang Lu,Yufeng Gao,Xianliang Liu,Jiang Man,Sijia Li,Nan Li,Menghan Wang,Xi Liu,Xuemei Chen,Weidong Zang,Qingwu Yang,Jian Wang

Neuroscience（2017）

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摘要

•We used crenolanib to study the role of PDGFR pathway in MCAO mice.•Crenolanib interfered with migration and survival of neuroblasts from SVZ to infarction.•Crenolanib decreased angiogenesis and chemo-attractants secretion in MCAO mice.•Crenolanib activated microglia and decreased neuroprotectants’ level in MCAO mice.•Crenolanib accelerated the apoptosis of pericytes in the peri-infarct area in MCAO mice.

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关键词

BBB,BDNF,cCasp3,DCX,IL-10,MCAO,MCP-1,mNSS,NT-3,PBS,PDGF,PDGFR,SDF-1,SVZ,VEGF

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