UPLC-MS/MS assay of riluzole in human plasma and cerebrospinal fluid (CSF): Application in samples from spinal cord injured patients.

Mahua Sarkar,Robert G Grossman,Elizabeth G Toups,Diana S-L Chow

Journal of Pharmaceutical and Biomedical Analysis（2017）

引用 8|浏览13

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摘要

•Development and validation of UPLC–MS/MS assay of riluzole in human plasma and CSF.•Assay validation as per US FDA Bioanalytical Method Validation: Guidance for Industry.•UPLC–MS/MS assay to quantify clinical samples from spinal cord injured patients.

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关键词

Riluzole,LC–MS/MS,Spinal cord injury,Plasma,CSF,Stability

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