LOX-1 is involved in IL-1β production and extracellular matrix breakdown in dental peri-implantitis

•LOX-1, IL-1β, MMP2 and MMP9 are involved in human dental peri-implantitis.•LOX-1 reduces P. gingivalis induced IL-1β production in macrophages.•JNK was responsible for LOX-1 induced IL-1β production upon P. gingivalis infection.•P. gingivalis induced MMP2 and MMP9 production in macrophages is dependent on LOX-1.