Activity-dependent changes in transporter and potassium currents in hippocampal astrocytes.

•Activity-dependent elevation of [K+]o enhances glutamate transporter current.•Activity-dependent prolongation of transporter current is abolished by Kir blockade.•Blockade of glutamate uptake facilitates activity-dependent K+ accumulation.•Glutamate and K+ elevations during synaptic transmission strongly interact.