DHEA prevents ribavirin-induced anemia via inhibition of glucose-6-phosphate dehydrogenase.
Antiviral Research(2017)
摘要
Ribavirin has been widely used for antiviral therapy. Unfortunately, ribavirin-induced anemia is often a cause of limiting or interrupting treatment. Our team has observed that dehydroepiandrosterone (DHEA) has a protective effect against in vitro and in vivo ribavirin-induced hemolysis. The aim of this study was to better understand this effect as well as the underlying mechanism(s).
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关键词
DHEA,Ribavirin,Anemia,Hemolysis,Glycolysis
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