Arc ubiquitination in synaptic plasticity.

•Learning-related neural activity leads to a transient increase in Arc protein.•Multiple forms of neural activity cause Arc ubiquitination.•Two E3 ligases that control Arc ubiquitination have been identified.•Defects in Arc ubiquitination disrupts AMPA receptor trafficking and synaptic plasticity.•Disruptions in Arc ubiquitination has implications for neurological disease.