Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor
NATURE CHEMICAL BIOLOGY（2017）
摘要
n inhibitor of the SUMO-activating (E1) enzyme SAE blocks enzyme activity and total SUMOylation in cells—thereby defining roles for SAE in mitotic progression and chromosome segregation—and also decreases cancer cell proliferation.
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关键词
Post-translational modifications,Proteins,Target validation,Chemistry/Food Science,general,Biochemical Engineering,Biochemistry,Cell Biology,Bioorganic Chemistry
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