CNPY2 is a key initiator of the PERK–CHOP pathway of the unfolded protein response

Feng Hong,Bei Liu,Bill X Wu,Jordan Morreall,Brady Roth,Christopher Davies,Shaoli Sun,J Alan Diehl,Zihai Li

NATURE STRUCTURAL & MOLECULAR BIOLOGY（2017）

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摘要

In vitro and in vivo data show that ER protein CNPY2 initiates the PERK–CHOP signaling pathway to trigger the unfolded protein response (UPR) and contributes to hepatic steatosis.

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关键词

Diseases,Endoplasmic reticulum,Life Sciences,general,Biochemistry,Protein Structure,Membrane Biology,Biological Microscopy

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