A one-pot radioiodination of aryl amines via stable diazonium salts: preparation of 125 I-imaging agents.

An operationally simple, one-pot, two-step tandem procedure that allows the incorporation of radioactive iodine into aryl amines via stable diazonium salts is described. The mild conditions are tolerant of various functional groups and substitution patterns, allowing latestage, rapid access to a wide range of I-125-labelled aryl compounds and SPECT radiotracers.