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Insulin Glargine and Its Two Active Metabolites: A Sensitive (16 Pm) and Robust Simultaneous Hybrid Assay Coupling Immunoaffinity Purification with LC–MS/MS to Support Biosimilar Clinical Studies

Yang Xu,Li Sun,Melanie Anderson, Philippe Belanger, Vincent Trinh, Patricia Lavallee,Bhavna Kantesaria, Marie-Josee Marcoux,Sheila Breidinger,Kevin P. Bateman,Dina Goykhman,Eric J. Woolf

Journal of Chromatography B（2017）

Cited 16|Views18
Key words
Insulin glargine and its active metabolites M1 and M2,Immunoaffinity purification (IAP),LC-MS/MS,Hybrid method,Biosimilar clinical studies
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