Oligonucleotide-conjugated Nanoparticles for Targeted Drug Delivery via Scavenger Receptors Class A: An In Vitro Assessment for Proof-of-concept.

Spherical nucleic acid gold nanoparticles represent a unique nanotechnology in which the spherical arrangement of oligonucleotides enables the nanoparticles to be efficiently internalized into cells expressing scavenger receptors class A (SR-A). Herein, we seek to replace the gold core with a biodegradable polymeric construct and explore their potential applications in targeted drug delivery.