Motion-robust parameter estimation in abdominal diffusion-weighted MRI by simultaneous image registration and model estimation.

•Motion-robust parameter estimation is needed in abdominal diffusion-weighted MRI.•We propose a novel simultaneous image registration and model estimation (SIR-ME) framework.•SIR-ME utilizes dependency of acquired b-value images along the diffusion-weighting dimension.•Jointly estimates transformations for the non-rigid alignment and signal decay model parameters.•Increases precision of parameters, improves discrimination of normal and diseased bowel.