Cardiac ScoreCard: A diagnostic multivariate index assay system for predicting a spectrum of cardiovascular disease

Michael P. McRae,Biykem Bozkurt,Christie M. Ballantyne,Ximena Sanchez,Nicolaos Christodoulides,Glennon Simmons,Vijay Nambi,Arunima Misra,Craig S. Miller,Jeffrey L. Ebersole,Charles Campbell,John T. McDevitt

EXPERT SYSTEMS WITH APPLICATIONS（2016）

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摘要

•We developed a Cardiac ScoreCard based on a multivariate index assay.•Using a single chip for multiple cardiac applications reduces cost and time.•Lasso logistic regression performs shrinkage and selection in multimarker models.•Biomarkers and traditional risk factors predict cardiac wellness and heart failure.

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关键词

Cardiovascular disease (CVD),Lasso logistic regression,Biomarkers,Cardiac wellness,Heart failure (HF),Programmable bio-nano-chip (p-BNC)

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