Developing the Quantitative Histopathology Image Ontology (QHIO): A case study using the hot spot detection problem.

•The Quantitative Histopathological Imaging Ontology (QHIO) is proposed.•QHIO facilitates interoperability between histopathology datasets and algorithms.•By enforcing data compatibility, QHIO enables large-scale collaborative studies.•Researchers can easily find data and algorithms to suit their experimental needs.•Designed with OBO principles, QHIO integrates with existing biomedical ontologies.