GTS-21 reduces microvascular permeability during experimental endotoxemia.

Karsten Schmidt,Sukanya Bhakdisongkhram,Florian Uhle,Christoph Philipsenburg,Aleksandar R Zivkovic,Thorsten Brenner,Johann Motsch,Markus A Weigand,Stefan Hofer

Microvascular Research（2018）

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摘要

•Intravital microscopy study•In-vivo effect of the partial α7nAChR-agonist GTS-21 on microvascular inﬂammation during LPS-induced endotoxemia in rats•GTS-21 has a protective effect on microvascular permeability if applied simultaneously or 1 h after endotoxemia induction•Leukocyte adhesion, venular wall shear rate and TNF- α levels were not affected by GTS-21 treatment

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