Loss of Sestrin 2 potentiates the early onset of age-related sensory cell degeneration in the cochlea.

Celia Zhang,Wei Sun,Ji Li,Binbin Xiong,Mitchell D Frye,Dalian Ding,Richard Salvi,Mi-Jung Kim,Shinichi Someya,Bo Hua Hu

Neuroscience（2017）

引用 26|浏览8

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摘要

•SESN2 is expressed in the mouse cochlear sensory epithelium.•Cochlear SESN2 expression decreases with aging.•Loss of SESN2 function potentiates age-related cochlear degeneration.•SESN2 deficiency provokes proinflammatory responses.

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关键词

ABR,ARHL,DAPI,GAPDH,KO,OHC,PBS,ROS,RT-qPCR,Tlr

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