Effects of blood lipid stability on progression of carotid atherosclerosis.

Objective: To evaluate the effects of blood lipid stability on progression of carotid atherosclerosis. Methods: A total of 416 patients who had physical examination in our hospital annually from January 2010 to December 2015 were selected and divided into a progression group (n=216) and a non-progression group (n=200) according to the intima-media thickness measured by carotid ultrasound. The levels of lipid related parameters within five years were retrospectively analyzed to calculate the smoothness index (SI = x rectangle/s). Results: The cross-sectional TG, HDL-C, ApoAI, ApoB, ApoE and Lpa levels were similar in the two groups (p>0.05). The non -progression group had significantly higher TC ((4.15 +/- 0.82 vs. 4.50 +/- 1.04) mmol/L) and LDL-C ((2.53 +/- 0.76 vs. 2.99 +/- 1.03) mmol/L) levels than those of the progression group (p<0.05).The progression group had significantly lower TC SI (5.29 +/- 1.28 vs. 5.65 +/- 1.76), TG SI (2.13 +/- 0.71 vs. 2.79 +/- 0.82), LDL-C SI (3.66 +/- 1.17 vs. 4.36 +/- 1.58), ApoB SI (3.37 +/- 0.88 vs. 3.62 +/- 0.95) and Lpa SI (1.53 +/- 0.49 vs. 1.62 +/- 0.43) than those of the non-progression group (p<0.05). Conclusion: Compared with cross-sectional results, SI was better correlated with the progression of atherosclerosis. The progression group had lower SI values.