A comprehensive study of smoking-specific microRNA alterations in head and neck squamous cell carcinoma.

Aswini R Krishnan,Hao Zheng,James G Kwok,Yuanhao Qu,Angela E Zou,Avinaash Korrapati,Pin Xue Li,Joseph A Califano,Melbourne F Hovell,Jessica Wang-Rodriguez,Weg M Ongkeko

Oral Oncology（2017）

引用 24|浏览14

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摘要

•RNA-seq analysis implicated 170 microRNAs in smoking-induced HNSCC.•Distinct panels of microRNAs correlated with tumor site, stage, and metastasis.•4 microRNAs associated with patient survival.•In vitro treatment with cigarette smoke extract verified microRNA dysregulation.

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关键词

HNSCC,miRNA,HPV,TCGA

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