Draft Genome Sequences Of Three Beta-Lactam-Catabolizing Soil Proteobacteria

Terence S Crofts,Bin Wang,Aaron Spivak,Tara A Gianoulis,Kevin J Forsberg,Molly K Gibson,Lauren A Johnsky,Stacey M Broomall,C Nicole Rosenzweig,Evan W Skowronski,Henry S Gibbons,Morten O A Sommer,Gautam Dantas

MICROBIOLOGY RESOURCE ANNOUNCEMENTS（2017）

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摘要

Most antibiotics are derived from the soil, but their catabolism there, which is necessary to close the antibiotic carbon cycle, remains uncharacterized. We report the first draft genome sequences of soil Proteobacteria identified for subsisting solely on beta-lactams as their carbon sources. The genomes encode multiple beta-lactamases, although their antibiotic catabolic pathways remain enigmatic.

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