mRNA 3′ uridylation and poly(A) tail length sculpt the mammalian maternal transcriptome

Marcos Morgan,Christian Much,Monica DiGiacomo,Chiara Azzi,Ivayla Ivanova,Dimitrios M. Vitsios,Jelena Pistolic,Paul Collier,Pedro N. Moreira,Vladimir Benes,Anton J. Enright,Dónal O’Carroll

NATURE（2017）

引用 157|浏览25

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摘要

TUT4 and TUT7 mediate 3′ uridylation of mRNA transcripts, preferentially those with short poly(A) tails; in the absence of TUT4 and TUT7, oocytes cannot mature and female mice are infertile.

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关键词

Embryogenesis,RNA decay,RNA modification,Science,Humanities and Social Sciences,multidisciplinary

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