Multiple amino acid substitutions involved in the virulence enhancement of an H3N2 avian influenza A virus isolated from wild waterfowl in mice.

Zhijun Yu,Weiyang Sun,Xinghai Zhang,Kaihui Cheng,Chuqi Zhao,Yuwei Gao,Xianzhu Xia

Veterinary Microbiology（2017）

引用 6|浏览37

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摘要

•H3N2 variants displayed enhanced replication in vivo.•H3N2 variants were capable of replicating in multiple organs of infected mice.•Some adaptive mutations were identified in natural H3 AIVs.

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关键词

Avian influenza A virus,H3N2,Wild birds,Mice,Pathogenicity

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