Rapid acquisition adaptive amino acid substitutions involved in the virulence enhancement of an H1N2 avian influenza virus in mice.

Zhijun Yu,Weiyang Sun,Xinghai Zhang,Kaihui Cheng,Chuqi Zhao,Xianzhu Xia,Yuwei Gao

Veterinary Microbiology（2017）

引用 7|浏览49

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摘要

•H1N2 variants displayed enhanced replication in vitro and in vivo.•H1N2 variants were capable of replicating in multiple organs of infected mice.•Some adaptive mutations were identified in natural H1 AIVs.

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关键词

Avian influenza virus,H1N2,Wild waterfowl,Adaptation,Mice

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