Probiotic Lactobacillus acidophilus bacteria or synthetic TLR2 agonist boost the growth of chicken embryo intestinal organoids in cultures comprising epithelial cells and myofibroblasts.

Malgorzata Pierzchalska,Malgorzata Panek,Malgorzata Czyrnek,Anna Gielicz,Barbara Mickowska,Maja Grabacka

Comparative Immunology, Microbiology and Infectious Diseases（2017）

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摘要

•The chicken intestinal organoids comprise epithelial cells and myofibroblasts.•The organoid cells express TLR4, TLR2 type 1 and TLR2 type 2 receptors.•TLR2 ligand Pam3CSK4 and Lactobacillus promote organoids growth and survival.•Pam3CSK4 stimulation boosts the PGE2 and PGD2 production by organoids and myofibroblasts.

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关键词

Toll-like receptors,Intestinal organoids,Intestinal myofibroblasts,Probiotics,Avian immunity

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