Activatable interpolymer complex-superparamagnetic iron oxide nanoparticles as magnetic resonance contrast agents sensitive to oxidative stress.

Eunsoo Yoo, Huaitzung A Cheng, Lauren E Nardacci, David J Beaman,Charles T Drinnan, Carmen Lee,Kenneth W Fishbein,Richard G Spencer,Omar Z Fisher,Amber L Doiron

Colloids and Surfaces B: Biointerfaces（2017）

引用 17|浏览11

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摘要

•An activatable T2 magnetic resonance contrast agent has been created.•Superparamagnetic iron oxide nanoparticles are encapsulated in complexed polymers.•The complexed polymers swell when oxidized, activating the contrast agent.•The activation is confirmed with measurements of MR relaxivity and size changes.

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关键词

Magnetic resonance imaging,Activatable contrast,Nanoparticles,Oxidative stress,Superparamagnetic iron oxide nanoparticles

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