Lipid profiling of the filarial nematodes Onchocerca volvulus, Onchocerca ochengi and Litomosoides sigmodontis reveals the accumulation of nematode-specific ether phospholipids in the host

International Journal for Parasitology(2017)

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摘要
•Onchocerciasis is an infectious disease caused by filarial nematodes.•Three different filarial nematodes infecting cattle, humans and jirds were studied.•Phospholipids in nematodes and hosts were determined by mass spectrometry.•Filaria-specific ether phosphatidylethanolamine (PE) lipids accumulate in the host.•These ether PE lipids could serve as potential biomarkers for onchocerciasis.
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关键词
Filariasis,Biomarker,Diagnosis,Phospholipid,Human,Gerbil,Jird,Cattle
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