PRDM15 safeguards naive pluripotency by transcriptionally regulating WNT and MAPK–ERK signaling

Slim Mzoughi,Jingxian Zhang,Delphine Hequet,Shun Xie Teo,Haitong Fang,Qiao Rui Xing,Marco Bezzi,Michelle Kay Yi Seah,Sheena L M Ong,Eun Myoung Shin,Heike Wollmann,Esther S M Wong,Muthafar Al-Haddawi,Colin L Stewart,Vinay Tergaonkar,Yuin-Han Loh,N Ray Dunn,Daniel M Messerschmidt,Ernesto Guccione

NATURE GENETICS（2017）

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摘要

Ernesto Guccione and colleagues report that the transcription factor PRDM15 regulates naive pluripotency in mouse embryos and embryonic stem cells and in derivation of mouse and human iPSCs. They further show that PRDM15 promotes WNT signaling and inhibits MAPK–ERK signaling by directly regulating the expression of R-spondin1 and Sprouty1, respectively.

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关键词

Epigenetics,Epigenomics,Stem cells,Biomedicine,general,Human Genetics,Cancer Research,Agriculture,Gene Function,Animal Genetics and Genomics

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