To4, the first Tityus obscurus β-toxin fully electrophysiologically characterized on human sodium channel isoforms.

Harry Morales Duque,Caroline Barbosa Farias Mourão,Diogo Vieira Tibery,Eder Alves Barbosa,Leandro Ambrósio Campos,Elisabeth Ferroni Schwartz

Peptides（2017）

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摘要

•To4 is the first toxin from Tityus obscurus venom characterized on hNav isoforms.•To4 shows a β-toxin effect when tested on human sodium channels isoforms.•To4 showed promiscuous activity on human sodium channels.

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关键词

β-Toxin,Human sodium channel isoforms,Na+-channel,NaScTx,Scorpion,Tityus obscurus venom,To4

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