Mean platelet volume predicts prognosis in patients with diffuse large B-cell lymphoma.

To determine the prognostic value of baseline mean platelet volume (MPV) in diffuse large B-cell lymphoma (DLBCL) patients. We retrospectively analyzed 161 DLBCL patients who received R-CHOP chemotherapy. The associations between MPV and clinicopathological factors were assessed. A low MPV (MPV 9.1 fl, cut-off was calculated by receiver operating characteristics) was not associated with any other clinicopathological factors. Patients with MPV9.1fl experienced a shorter progression-free survival (PFS) (2-year PFS rate, 60.6% vs 84.0%, P=0.003) and overall survival (OS) (2-year OS rate, 70.4% vs 87.9%, P=0.030), compared with those with MPV>9.1fl. The multivariate analysis demonstrated that MPV9.1fl was an independent prognostic factor of OS (Hazard Ratio [HR]=0.588, P=0.045) and PFS (HR=0.456, P=0.010). Therefore, we demonstrated that low baseline MPV is an independent prognostic marker of poor outcome in patients with DLBCL.