Analytical and clinical performance of the Hologic Aptima HCV Quant Dx Assay for the quantification of HCV RNA in plasma samples.

•Aptima HCV Quant Dx and CAPCTMv2 HCV tests were highly correlated and inclusive.•The Aptima assay appeared more analytical sensitive than the CAPCTMv2 test.•Linear responses differed with Aptima yielding higher viral loads for HCV-RNA>4.9 Log IU/mL.•Both tests yielded interpretable results when used for monitoring antiviral treatment responses.•Both tests are useful for monitoring patients with HCV infection.