Schlafen 14 (SLFN14) is a novel antiviral factor involved in the control of viral replication

•The role of SLFN14 during viral infection is currently unknown.•Influenza A infection led to the induction of SLFN14 expression.•SLFN14 enhances RIG-I-mediated signaling and inhibits influenza replication.•SLFN14 also restricts Varicella Zoster Virus (DNA virus) antigen expression.