Measurement of Oncometabolites D-2-Hydroxyglutaric Acid and L-2-Hydroxyglutaric Acid.

Patricia M Jones,Richard Boriack,Eduard A Struys,Dinesh Rakheja

Methods in molecular biology (Clifton, N.J.)（2017）

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摘要

We describe a liquid chromatography-tandem mass spectrometry assay for measurement of D-2-hydroxyglutaric acid and L-2-hydroxyglutaric acid. These metabolites are increased in specific inborn errors of metabolism and are now recognized as oncometabolites. The measurement of D-2-hydroxyglutarate in peripheral blood may be used as a biomarker for screening and follow-up of patients with IDH-mutated acute myeloid leukemia.

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关键词

2-Hydroxyglutaric acid,2HG,Biomarker,D-2-Hydroxyglutaric acid,D-2HG,L-2-Hydroxyglutaric acid,L-2HG,LC-MS/MS,Liquid chromatography-tandem mass spectrometry,Oncometabolite

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