Ethnic heterogeneity and prostate cancer mortality in Hispanic/Latino men: a population-based study.

Background: Few studies focus on prostate cancer (PCa) outcomes in Hispanic/Latino men. Our study explores whether Hispanic/Latino subgroups demonstrate significantly different prostate cancer-specific mortality (PCSM) relative to Non-Hispanic White (NHW) and Non-Hispanic Black (NHB) men. Methods: We extracted a population-based cohort of men diagnosed with local-regional PCa from 2000-2013 (n = 486,865). PCSM was measured in racial/ethnic groups: NHW (n = 352,886), NHB (n = 70,983), Hispanic/Latino (n = 40,462), and Asian American/Pacific Islander (n = 22,534). PCSM was also measured in Hispanic/Latino subgroups: Mexican (n = 8,077), Puerto Rican (n = 1,284), South or Central American (n = 3,021), Cuban (n = 788), and Dominican (n = 300). We conducted univariable and multivariable analyses (MVA) to compare risk for PCSM. Results: Compared to NHW men, results showed worse outcomes for NHB men with similar outcomes for Hispanic/Latino men. In MVA with NHW men as a reference, NHB (HR = 1.15, p < 0.001) men had significantly worse PCSM and Hispanic/Latino ( HR = 1.02, p = 0.534) men did not show a significant difference. In a second MVA, Puerto Rican (HR = 1.71, p < 0.001) and Mexican (HR = 1.21, p = 0.008) men had significantly higher PCSM. With NHB men as a reference, the MVA showed Puerto Rican (HR = 1.50, p = 0.006) men with higher PCSM and Mexican (HR = 1.08, p = 0.307) men with no significant difference. Conclusions: Our findings indicate previously unknown disparities in PCSM for Puerto Rican and Mexican American men.