In situ adjuvant therapy using a responsive doxorubicin-loaded fibrous scaffold after tumor resection.

Ziming Yuan,Wei Wu,Zhongwei Zhang,Zhiyong Sun,Ruoyu Cheng,Guoqin Pan,Xuemin Wang,Wenguo Cui

Colloids and Surfaces B: Biointerfaces（2017）

引用 12|浏览4

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摘要

•Electrospun fibrous scaffold with acid sensitive “switch”.•A sustained pH-sensitive release for long-term inhibiting tumors.•The anti-cancer effects with decreasing Bcl-2 and TNF-α expression.•Prevent tumor recurrence for a relatively long term.

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关键词

Breast cancer,Implantable scaffold,Electrospun fibers,Mesoporous silica nanoparticles

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